Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway.

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“The Gift Of The Magi” by O Henry

One dollar and eighty-seven cents. That was all. And sixty cents of it was in pennies. Pennies saved one and two at a time by bulldozing the grocer and the vegetable man and the butcher until one’s cheeks burned with the silent imputation of parsimony that such close dealing implied. Three times Della counted it. One dollar and eighty-seven cents. And the next day would be Christmas.

There was clearly nothing to do but flop down on the shabby little couch and howl. So Della did it. Which instigates the moral reflection that life is made up of sobs, sniffles, and smiles, with sniffles predominating.

While the mistress of the home is gradually subsiding from the first stage to the second, take a look at the home. A furnished flat at $8 per week. It did not exactly beggar description, but it certainly had that word on the lookout for the mendicancy squad. In the vestibule below was a letter-box into which no letter would go, and an electric button from which no mortal finger could coax a ring. Also appertaining thereunto was a card bearing the name “Mr. James Dillingham Young.” The “Dillingham” had been flung to the breeze during a former period of prosperity when its possessor was being paid $30 per week. Now, when the income was shrunk to $20, the letters of “Dillingham” looked blurred, as though they were thinking seriously of contracting to a modest and unassuming D. But whenever Mr. James Dillingham Young came home and reached his flat above he was called “Jim” and greatly hugged by Mrs. James Dillingham Young, already introduced to you as Della. Which is all very good.

Della finished her cry and attended to her cheeks with the powder rag. She stood by the window and looked out dully at a grey cat walking a grey fence in a grey backyard. Tomorrow would be Christmas Day, and she had only $1.87 with which to buy Jim a present. She had been saving every penny she could for months, with this result. Twenty dollars a week doesn’t go far. Expenses had been greater than she had calculated. They always are. Only $1.87 to buy a present for Jim. Her Jim. Many a happy hour she had spent planning for something nice for him. Something fine and rare and sterling– something just a little bit near to being worthy of the honour of being owned by Jim.

There was a pier-glass between the windows of the room. Perhaps you have seen a pier-glass in an $8 flat. A very thin and very agile person may, by observing his reflection in a rapid sequence of longitudinal strips, obtain a fairly accurate conception of his looks. Della, being slender, had mastered the art.

Suddenly she whirled from the window and stood before the glass. Her eyes were shining brilliantly, but her face had lost its colour within twenty seconds. Rapidly she pulled down her hair and let it fall to its full length.

Now, there were two possessions of the James Dillingham Youngs in which they both took a mighty pride. One was Jim’s gold watch that had been his father’s and his grandfather’s. The other was Della’s hair. Had the Queen of Sheba lived in the flat across the airshaft, Della would have let her hair hang out the window some day to dry just to depreciate Her Majesty’s jewels and gifts. Had King Solomon been the janitor, with all his treasures piled up in the basement, Jim would have pulled out his watch every time he passed, just to see him pluck at his beard from envy.

So now Della’s beautiful hair fell about her, rippling and shining like a cascade of brown waters. It reached below her knee and made itself almost a garment for her. And then she did it up again nervously and quickly. Once she faltered for a minute and stood still while a tear or two splashed on the worn red carpet.

On went her old brown jacket; on went her old brown hat. With a whirl of skirts and with the brilliant sparkle still in her eyes, she fluttered out the door and down the stairs to the street.

Where she stopped the sign read: “Mme. Sofronie. Hair Goods of All Kinds.” One flight up Della ran, and collected herself, panting. Madame, large, too white, chilly, hardly looked the “Sofronie.”

“Will you buy my hair?” asked Della.

“I buy hair,” said Madame. “Take yer hat off and let’s have a sight at the looks of it.”

Down rippled the brown cascade. “Twenty dollars,” said Madame, lifting the mass with a practised hand.

“Give it to me quick,” said Della.

Oh, and the next two hours tripped by on rosy wings. Forget the hashed metaphor. She was ransacking the stores for Jim’s present.

She found it at last. It surely had been made for Jim and no one else. There was no other like it in any of the stores, and she had turned all of them inside out. It was a platinum fob chain simple and chaste in design, properly proclaiming its value by substance alone and not by meretricious ornamentation–as all good things should do. It was even worthy of The Watch. As soon as she saw it she that it must be Jim’s. It was like him. Quietness and value– the description applied to both. Twenty-one dollars they took from her for it, and she hurried home with the 87 cents. With that chain on his watch Jim might be properly anxious about the time in any company. Grand as the watch was, he sometimes looked at it on the sly on account of the old leather strap that he used in place of a chain.

When Della reached home her intoxication gave way a little to prudence and reason. She got out her curling irons and lighted the gas and went to work repairing the ravages made by generosity added to love. Which is always a tremendous task, dear friends–a mammoth task.

Within forty minutes her head was covered with tiny, close-lying curls that made her look wonderfully like a truant schoolboy. She looked at her reflection in the mirror long, carefully, and critically.

“If Jim doesn’t kill me,” she said to herself, “before he takes a second look at me, he’ll say I look like a Coney Island chorus girl. But what could I do–oh! what could I do with a dollar and eighty- seven cents?”

At 7 o’clock the coffee was made and the frying-pan was on the back of the stove hot and ready to cook the chops.

Jim was never late. Della doubled the fob chain in her hand and sat on the corner of the table near the door that he always entered. Then she heard his step on the stair away down on the first flight, and she turned white for just a moment. She had a habit for saying little silent prayers about the simplest everyday things, and now she whispered: “Please God, make him think I am still pretty.”

The door opened and Jim stepped in and closed it. He looked thin and very serious. Poor fellow, he was only twenty-two–and to be burdened with a family! He needed a new overcoat and he was without gloves.

Jim stopped inside the door, as immovable as a setter at the scent of quail. His eyes were fixed upon Della, and there was an expression in them that she could not read, and it terrified her. It was not anger, nor surprise, nor disapproval, nor horror, nor any of the sentiments that she had been prepared for. He simply stared at her fixedly with that peculiar expression on his face.

Della wriggled off the table and went for him.

“Jim, darling,” she cried, “don’t look at me that way. I had my hair cut off and sold because I couldn’t have lived through Christmas without giving you a present. It’ll grow out again–you won’t mind, will you? I just had to do it. My hair grows awfully fast. Say ‘Merry Christmas!’ Jim, and let’s be happy. You don’t know what a nice–what a beautiful, nice gift I’ve got for you.”

“You’ve cut off your hair?” asked Jim, laboriously, as if he had not arrived at that patent fact yet even after the hardest mental labor.

“Cut it off and sold it,” said Della. “Don’t you like me just as well, anyhow? I’m me without my hair, ain’t I?”

Jim looked about the room curiously.

“You say your hair is gone?” he said, with an air almost of idiocy.

“You needn’t look for it,” said Della. “It’s sold, I tell you–sold and gone, too. It’s Christmas Eve, boy. Be good to me, for it went for you. Maybe the hairs of my head were numbered,” she went on with sudden serious sweetness, “but nobody could ever count my love for you. Shall I put the chops on, Jim?”

Out of his trance Jim seemed quickly to wake. He enfolded his Della. For ten seconds let us regard with discreet scrutiny some inconsequential object in the other direction. Eight dollars a week or a million a year–what is the difference? A mathematician or a wit would give you the wrong answer. The magi brought valuable gifts, but that was not among them. This dark assertion will be illuminated later on.

Jim drew a package from his overcoat pocket and threw it upon the table.

“Don’t make any mistake, Dell,” he said, “about me. I don’t think there’s anything in the way of a haircut or a shave or a shampoo that could make me like my girl any less. But if you’ll unwrap that package you may see why you had me going a while at first.”

White fingers and nimble tore at the string and paper. And then an ecstatic scream of joy; and then, alas! a quick feminine change to hysterical tears and wails, necessitating the immediate employment of all the comforting powers of the lord of the flat.

For there lay The Combs–the set of combs, side and back, that Della had worshipped long in a Broadway window. Beautiful combs, pure tortoise shell, with jewelled rims–just the shade to wear in the beautiful vanished hair. They were expensive combs, she knew, and her heart had simply craved and yearned over them without the least hope of possession. And now, they were hers, but the tresses that should have adorned the coveted adornments were gone.

But she hugged them to her bosom, and at length she was able to look up with dim eyes and a smile and say: “My hair grows so fast, Jim!”

And them Della leaped up like a little singed cat and cried, “Oh, oh!”

Jim had not yet seen his beautiful present. She held it out to him eagerly upon her open palm. The dull precious metal seemed to flash with a reflection of her bright and ardent spirit.

“Isn’t it a dandy, Jim? I hunted all over town to find it. You’ll have to look at the time a hundred times a day now. Give me your watch. I want to see how it looks on it.”

Instead of obeying, Jim tumbled down on the couch and put his hands under the back of his head and smiled.

“Dell,” said he, “let’s put our Christmas presents away and keep ’em a while. They’re too nice to use just at present. I sold the watch to get the money to buy your combs. And now suppose you put the chops on.”

The magi, as you know, were wise men–wonderfully wise men–who brought gifts to the Babe in the manger. They invented the art of giving Christmas presents. Being wise, their gifts were no doubt wise ones, possibly bearing the privilege of exchange in case of duplication. And here I have lamely related to you the uneventful chronicle of two foolish children in a flat who most unwisely sacrificed for each other the greatest treasures of their house. But in a last word to the wise of these days let it be said that of all who give gifts these two were the wisest. Of all who give and receive gifts, such as they are wisest. Everywhere they are wisest. They are the magi.

 

“The Tale of Three Trees” -Author Unknown

Once upon a mountain top, three little trees stood and dreamed of what they wanted to become when they grew up. The first little tree looked up at the stars and said: “I want to hold treasure. I want to be covered with gold and filled with precious stones. I’ll be the most beautiful treasure chest in the world!” The second little tree looked out at the small stream trickling by on its way to the ocean. “I want to be traveling mighty waters and carrying powerful kings. I’ll be the strongest ship in the world!” The third little tree looked down into the valley below where busy men and women worked in a busy town. “I don’t want to leave the mountain top at all. I want to grow so tall that when people stop to look at me, they’ll raise their eyes to heaven and think of God. I will be the tallest tree in the world.”

Years passed and the little trees grew tall. One day three woodcutters climbed the mountain. The first woodcutter looked at the first tree and said, “This tree is beautiful. It is perfect for me.” With a swoop of his shining ax, the first tree fell. “Now I shall be made into a beautiful chest, I shall hold wonderful treasure!” the first tree said. The second woodcutter looked at the second tree and said, “This tree is strong. It is perfect for me.” With a swoop of his shining ax, the second tree fell. “Now I shall sail mighty waters!” thought the second tree. “I shall be a strong ship for mighty kings!” The third tree felt her heart sink when the last woodcutter looked her way. She stood straight and tall and pointed bravely to heaven. But the woodcutter never even looked up. “Any kind of tree will do for me.” He muttered. With a swoop of his shining ax the third tree fell.

The first tree rejoiced when the woodcutter brought her to a carpenter’s shop. But the carpenter fashioned the tree into a feed box for animals. The once beautiful tree was not covered with gold, nor with treasure. She was coated with sawdust and filled with hay for hungry farm animals. The second tree smiled when the woodcutter took her to a shipyard, but no mighty ship was made that day. Instead, the once strong tree was hammered and sawed into a simple fishing boat. She was too small and too weak to sail to an ocean, or even a river. Instead she was taken to a little lake. The third tree was confused when the woodcutter cut her into strong beams and left her in a lumberyard. “What happened?” The once tall tree wondered. “All I ever wanted was to stay on the mountain top and point to God…”

Many, many days and nights passed. The three trees nearly forgot their dreams. But one night, golden starlight poured over the first tree as a young woman placed her newborn baby in the feed box. “I wish I could make a cradle for him,” her husband whispered. The mother squeezed his hand and smiled as the starlight shone on the smooth and the sturdy wood. “This manger is beautiful,” she said. And suddenly the first tree knew he was holding the greatest treasure in the world.

One evening a tired traveler and his friends crowded into the old fishing boat. The traveler fell asleep as the second tree quietly sailed out into the lake. Soon a thundering and thrashing storm arose. The little tree shuddered. She knew she did not have the strength to carry so many passengers safely through the wind and the rain. The tired man awakened. He stood up, stretched out his hand and said, “Peace.” The storm stopped as quickly as it had begun. And suddenly the second tree knew he was carrying the King of heaven and earth.

One Friday morning, the third tree was startled when her beams were yanked from the forgotten woodpile. She flinched as she was carried through an angry jeering crowd. She shuddered when soldiers nailed a man’s hands to her. She felt ugly and harsh and cruel. But on Sunday morning, when the sun rose and the earth trembled with joy beneath her, the third tree knew that God’s love had changed everything. It had made the third tree strong. And every time people thought of the third tree, they would think of God.

That was better than being the tallest tree in the world.

So the next time you feel down because you didn’t get what you want, just sit tight and be happy because God is thinking of something better to give you.

 

Christmas: Myth Became Fact

December 24
Myth Became Fact
The essential meaning of all things came down from the ‘heaven’ of myth and to the ‘earth’ of history. In so doing, it partly emptied itself of its glory, as Christ emptied Himself of His glory to be Man….That is why the New Testament is….less poetical than the Old. Have you not often felt in church, if the first lesson is some great passage, that the second lesson is somehow small by comparison – almost, if one might say so, humdrum? So it is and so it must be. That is the humiliation of myth into fact, of God into Man; what is everywhere and always, imageless and ineffable, only to be glimpsed in dream and symbol and the acted poetry of ritual becomes small, solid – no bigger than a man who can lie asleep in a rowing boat on the Lake of Galilee.
-“The Business of Heaven” Daily Readings from C.S. Lewis

“Love” excerpted from “The Baronet’s Song” by George MacDonald

Love

He was….one who did not make the common miserable blunder of taking the shadow cast by love – the desire, namely, to be loved – for love itself; his love was a vertical sun, and his own shadow was under his feet….But do not mistake me through confounding, on the other hand, the desire to be loved – which is neither wrong nor noble, any more than hunger is either wrong or noble – and the delight in being loved, to be devoid of which a man must be lost in an immeasurably deeper, in an evil, ruinous, yea, a fiendish selfishness.

 

Day 332


-from George MacDonald’s “Sir Gibbie/The Baronet’s Song”: An Anthology – 365 readings by CS Lewis

“How to Become a Dunce” excerpted from “The Baronet’s Song” by George MacDonald

Day 331

 

Naturally capable, he had already made of himself rather a dull fellow; for when a man spends his energy on appearing to have, he is all the time destroying what he has, and therein the very means of becoming what he desires to seem. If he gains his end, his success is his punishment.

 

-excerpted from George MacDonald’s “Sir Gibbie/The Baronet’s Song”: An Anthology – 365 readings by CS Lewis